MEGGLE, GERMANY

CO-PROCESSED EXCIPIENTS

Product

Particle Size (in µm)

(Typical Values)

Composition

Benefits

Applications

D50

D90

Cellactose® 80

167

298

75 % Lactose Monohydrate

25 % Powdered Cellulose

  • · Excellent compactibility and flowability
  • · Perfectly suited for poorly compressible APIs
  • · High adherence capacity to API
  • · Ideal tablet surface for easy and economical coating
  • · High adherence capacity may prevent segregation and improves content uniformity
  • · Direct compression
  • · Dry granulation (Roller compaction, slugging)
  • · Capsule filling

MicroceLac® 100

141

261

75% Alpha-Lactose Monohydrate

25% Microcrystalline Cellulose

  • · Excellent compactability and flowability
  • · Ideal for poorly compactable APIs, e.g. herbal extracts
  • · Ideal tablet surface for straight forward and economical coating
  • · High adherence capacity prevents segregation and subsequently improves content uniformity
  • · Direct compression
  • · Dry granulation (Roller compaction, slugging)
  • · Capsule filling

MicroceLac® Plus

75

134

35% Alpha-Lactose Monohydrate

65% Microcrystalline cellulose

  • · Outstanding tabletability
  • · Exceptional compressibility
  • · High tablet hardness with very low friability even at high drug loads
  • · Synergistic effect of the co-processing in terms of tabletability and flowability
  • · No capping tendency
  • · Very smooth tablet surface for easy and economical coating
  • · Reduction in tablet size

  • · Primarily designed for direct compression and continuous direct compression
  • · Direct compression of difficult-to-process APIs
  • · Formulations with high API content
  • · Suitable for mini-tablets
  • · Easy and economical coating

CombiLac®

176

283

70% Alpha-Lactose Monohydrate

20 % Microcrystalline Cellulose

10 % Native Corn Starch

  • · Excellent compactibility
  • · Excellent flowability
  • · Fast, hardness-independent tablet disintegration for effective API release
  • · Low friability
  • · Overcomes individual ingredient compaction and handling limitations
  • · Direct compression
  • · ODT formulations
  • · Dry granulation (Roller compaction, slugging)

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